Scientist/ Research Associate AI Protein Design

Computational Protein Design Scientist

Systimmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data-driven approaches to augment our first-in-class multi-specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.

Responsibilities

• Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display-based protein discovery platforms
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
• Analyze, interpret, document, and present data to the scientific and leadership team
• Collaborate with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams to contribute to the company's vision

Qualifications

• PhD: (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field
• Experience: 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required
• Software: Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrdinger)
• Screening Expertise: Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET)
• Contribution: Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable

Compensation and Benefits

The expected base salary range for this position is $80,000 - $180,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate's qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise align strongly with the requirements of the role. SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE. SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.