Postdoctoral Research Fellow

Job Summary

Postdoctoral fellow to work full-time on understanding the functions of protein post-translational modifications in human cancers. The research will focus on the regulatory mechanisms and physiological functions of arginine methylation in genomic instability, metabolism, cell signaling, and cancer progression, as well as exploring druggable targets for cancer therapy. Studies will use a range of complementary methods including biochemistry, molecular and cellular biology, functional cell-based assays and mouse genetic models. More details can be found in lab website https://www.wenjianganlab.com/.

Job Duties

• Using molecular biology and cell culture models to dissect questions related to arginine methylation. These duties include DNA/RNA purification, plasmid construction, PCR, RT-qPCR, cell culture, transfection, protein exaction, immunoprecipitation, western blot, cell proliferation, and colony formation.
• Using genetic mouse models to study the role of arginine methylation in cancer progression and metastasis. These duties include genotyping of mice, mice maintenance, mice breeding, drug treatment studies, monitoring for cancer development.
• Collaborates with the PI to prepare manuscripts and grants. Duties include preparing figures based on data collected, writing manuscripts and grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs.
• Collaborates with other lab members to maintain the laboratory, including making buffers, equipment maintenance, cleanup of lab areas, monitoring usage and deliver of lab supplies.

Job Qualifications

• The candidate should be highly motivated and within three years of receiving a Ph.D. or M.D./Ph.D. degree.
• The candidate should have a solid background and strong technical skills in biochemistry, molecular biology, cell biology, cancer biology, and mouse models.
• The candidate should have a publication track record.

Case Western Reserve School of Medicine

Since 1843, the Case Western Reserve School of Medicine has been at the forefront of medical education, innovating in biomedical research and training the next generation of physicians, scientists, and medical professionals. Dedicated to supporting community healthcare both locally and globally, the school continues to advance medical knowledge and improve patient care outcomes.

Contact

Interested candidates should send a cover letter describing current and future research interests, a current CV with names and contact information for 2-3 references to Dr. Wenjian Gan at Email: wxg208@case.edu.